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🤓This being said, it would be great to see full data, hopefully including changes in body composition and physical fitness - if not here, then perhaps in some later trials 🤓Looking forward to full data presentation and also to further trials looking into possible cardioprotective and nephroprotective effects and influence on other complications of obesity 😎 #cagrisema #tirzepatide #cagrilintide #semaglutide #obesity #weightloss #REDEFINE4 Martin Haluzík’s Post ❗Novo Nordisk A/S: 𝐂𝐚𝐠𝐫𝐢𝐒𝐞𝐦𝐚 𝐝𝐞𝐦𝐨𝐧𝐬𝐭𝐫𝐚𝐭𝐞𝐝 23% 𝐰𝐞𝐢𝐠𝐡𝐭 𝐥𝐨𝐬𝐬 𝐢𝐧 𝐚𝐧 𝐨𝐩𝐞𝐧-𝐥𝐚𝐛𝐞𝐥 𝐡𝐞𝐚𝐝-𝐭𝐨-𝐡𝐞𝐚𝐝 𝐑𝐄𝐃𝐄𝐅𝐈𝐍𝐄 4 𝐭𝐫𝐢𝐚𝐥 𝐢𝐧 𝐩𝐞𝐨𝐩𝐥𝐞 𝐰𝐢𝐭𝐡 𝐨𝐛𝐞𝐬𝐢𝐭𝐲, 𝐭𝐡𝐞 𝐩𝐫𝐢𝐦𝐚𝐫𝐲 𝐞𝐧𝐝𝐩𝐨𝐢𝐧𝐭 𝐰𝐚𝐬 𝐧𝐨𝐭 𝐚𝐜𝐡𝐢𝐞𝐯𝐞𝐝❗ ✍REDEFINE 4 was an 84-week trial investigating CagriSema (a fixed dose combination of cagrilintide 2.4 mg and semaglutide 2.4 mg) compared to tirzepatide 15 mg, both administered once-weekly and subcutaneously
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The mechanism by which LMP1 acts is posited to be via mimicry of CD40 signaling, which promotes B-cell proliferation, survival, and immune evasion [38, 40]
